• Nootropil 20% 5 ml №12 (in ampoules)

Nootropil 20% 5 ml №12 (in ampoules)

Description for Nootropil 20% 5 ml №12 (in ampoules)

Pharmacological properties
Active component Nootropil ® is a piracetam, a cyclic derivative of gamma-aminobutyric acid. Piracetam is a nootropic drugs, which acts on the brain, improving cognitive (cognitive) processes such as learning ability, memory, attention, and mental disability. Nootropil affects the central nervous system in different ways: by changing rate of spread of excitation in the brain, enhancing metabolic processes in nerve cells, improving microcirculation, influencing the rheological properties of blood and causing vasodilatory action. Improves communication between the hemispheres of the brain and the main synaptic conductance in neocortical structures. Piracetam inhibits platelet aggregation and restores the elasticity of red blood cell membranes, reduces adhesion of red blood cells. At a dose of 9.6 g reduces the level of fibrinogen and factors Villibranda by 30-40% and prolongs bleeding time. Piracetam promotes Treads and restoration efforts, in violation of the principal functions of the brain due to hypoxia and intoxication. Piracetam reduces the severity and duration of vestibular nystagmus.

Pharmacokinetics
The maximum concentration which can be achieved in blood after 30 minutes and 5 hours in the cerebrospinal fluid after intravenous administration of 40-60 micrograms / ml. The volume of distribution of piracetam almost 0.6 L / kg. The half-life of the drug from the plasma of 4-5 hours and 8.5 hours from the cerebrospinal fluid, prolonged in renal failure. Does not bind to plasma proteins, not metabolized in the body. 80-100% piracetam excreted by the kidneys as unchanged by renal filtration. Renal clearance of piracetam in healthy volunteers is 86 ml / min. Pharmacokinetics of piracetam is not changed in patients with liver failure. Piracetam crosses the blood-brain, placenta and membranes that are used in hemodialysis. When an animal study piracetam selectively accumulates in the tissues of the bark of the main brain, predominantly in the frontal, parietal and occipital lobes, the cerebellum and basal ganglia.

Indications for Use
Symptomatic treatment psychoorganic syndrome in elderly patients who suffer from memory loss, dizziness, reduced attention span and general activity, mood changes, behavioral disorders, gait disturbance, as well as in patients with Alzheimer's disease and senile dementia such as Alzheimer's. Chronic alcoholism - for the treatment of psychoorganic and withdrawal syndromes. Comatose state (and in the convalescence period), including after the injury and intoxication of the brain. Treatment of vertigo and related disorders of balance, with the exception of dizziness vasomotor and psychological origin. For treatment of cortical myoclonus as a mono-or combined therapy. In the treatment of sickle cell anemia.

Dosing and Administration
Adult daily dose is 30-160 mg / kg body weight (multiplicity of 2-3 times a day). Nootropil used IM or IV, from 2-4 g and rapidly increase the dose to 4-6 grams per day. The duration of treatment and selection of individual doses in these cases depends on the severity of the patient and the rate of return dynamics of clinical disease. After moving to improve the reception of internally. When sickle-cell anemia daily prophylactic dose of 160mg/kg body weight, divided into 4 equal parts. During a crisis - 300 mg / kg in. Daily doses for children (if you can not use oral forms): 1 to 3 years - 400 mg per day, from 3 to 7 years - 400-1000 mg per day, from 7 to 12 years - 400-2000 mg / day; 12 to 16 years - 800-2400 mg per day. Dosing in patients with impaired renal function. Since Nootropil excreted by the kidneys, caution should be exercised when treating patients with renal failure, following a treatment regimen.: Degree of renal creatinine clearance (ml / min.) Dosage No> 80 The usual dose of 50-79 Easy 2 / 3 usual dose for 2.3 introduction Average 30-49 1 / 3 usual dose for 2 of the introduction Severe <30 1 / 6, usual dose for 1-stage injection - contraindicated Adapting the dose is not necessary for patients with impaired liver function.

Side Effects
Side effects are more common in elderly patients who receive doses above 2.4 g / day. In most cases it is possible to achieve regression of these symptoms, reducing the dose of the drug .. There are few reports of adverse events in the nervous system - dizziness, headache, ataxia, imbalance, exacerbation of epilepsy, insomnia, marked by mental excitement, anxiety, nervnoznost, hallucinations, increased sexuality, rarely, lethargy and depression, from the skin cover - dermatitis, itching, rash, edema.

Contraindications
Individual intolerance of piracetam or pyrrolidone derivatives, as well as other components of the drug. Acute cerebral blood flow (hemorrhagic stroke). End-stage renal disease (with creatinine clearance below 20 ml / min). Children up to age 1 year.

Interaction with other drugs
In a joint application with thyroid hormones (TK + T4) may increase irritability, disorientation, and sleep disorders. There was no interaction with clonazepam, phenytoin, phenobarbital, sodium valproate. High doses (9.6 g / far) Piracetam increased efficiency atsenokumarola in patients with venous thrombosis: there was a significant reduction in platelet aggregation, fibrinogen, factors Willebrandt, blood viscosity and plasma. Ability to change the pharmacodynamics of piracetam under the influence of other drugs is low, since 90% of the drug appears unchanged in the urine. UN vitro piracetam does not inhibit cytochrome P450 isoforms SUR1A2, 2V6, 2S8, 2S9, 2S19, 2D6, 2E1 and 4A9/11 at a concentration of 142, 426, 1422 ug / ml. At a concentration of 1,422 ug / ml was a slight depression SUR2A6 (21%) and ZA4 / 5 (11%). However, the level of these two RMS Ki-isomers sufficient in excess of 1,422 ug / ml. Therefore, the metabolic interactions with drugs that undergo biotransformation of these enzymes is unlikely. Acceptance of piracetam in a dose 20mg/sut did not alter the peak of the curve and the concentration level protivoєpilepticheskih-administered drugs (carbamazepine, phenytoin, phenobarbital, valproate) in patients with epilepsy. Concomitant with alcohol had no effect on the concentration of piracetam in the serum and the concentration of alcohol in the blood serum did not change when receiving 1.6 g piracetam.

Features of
Due to the influence of piracetam on platelet aggregation, caution is recommended in the appointment of the drug to patients with hemostatic disorders, a time of surgery or patients with symptoms of severe bleeding. When treating patients with cortical myoclonus should avoid abrupt interruption of treatment because it may cause the resumption of attacks. Long-term therapy in patients with advanced age are advised to regularly monitor the performance of renal function, if necessary, adjust the dose depending on the research results of creatinine clearance. Given the possible side effects, caution should be followed when working with machinery and driving. Permeates through the membrane filter apparatus for hemodialysis. Pregnancy and lactation. Studies in animals showed no adverse effect on the embryo and its development, including in the postnatal period, piracetam did not change during pregnancy and childbirth. Experience with the drug in pregnant women do not. Piracetam crosses the placental barrier and into breast milk. Drug concentration in infants up to 70-90% of its concentration in the blood of the mother. Except in special circumstances, Nootropil not prescribed during pregnancy. Should refrain from breastfeeding in the appointment of a woman piracetam.

Conditions and terms of
Maintained at a temperature of 15-25 ° C in a dry place. Keep out of reach of children. Shelf life 5 years.

Conditions of supply
On prescription

Packing
Solution for injection 20% in the ampoule a g/5ml to 12 vials in the package; Zg/15ml - 4 capsules in the package

Nootropil 20% 5 ml №12 (in ampoules)

  • Product Code: 87
  • Availability: In Stock
  • $32.00

  • Ex Tax: $32.00

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