Prefolic is a complex of folic and citric acids, glutathione, mannitol, methyl p-hydroxybenzoate and sodium hydroxide. Supplies the body with folic acid and serves as a catalyst for its renewal processes. The drug increases energy and efficiency of sports activities.

The main area of application of the drug Prefolic (Prefolic) is the area of folic acid deficiency anemia, where the drug acts as the main supplier of folic acid, regulating the main catalytic processes through its strongest catalytic properties. In cases of antidote therapy, in particular overdose of antagonists, blocking the side effects of methotrexate and aminopterin. It is also used as one of the main components of the widely known Milanese cocktail.

Participates as a coenzyme in various enzymatic reactions, plays an important role in the metabolism of amino acids, the biosynthesis of purine and pyrimidine bases - a component of nucleic acids. This determines the importance of vitamin B9 for the normal processes of tissue growth and development. Vitamin B9 is also important for the processes of hematopoiesis and embryogenesis. Positively affects the functioning of the digestive tract. Lack of vitamin B9 inhibits the process of hematopoiesis. Its absence causes a special type of anemia, affecting the digestive system. Vitamin B9 takes part in the synthesis of muscle proteins. In bodybuilding, the need for folic acid is higher than in a normal lifestyle. Prescribed for macrocytic hyperchromic anemia caused by a lack of folic acid. It is also taken as one of the elements of the complex against anemia caused by long-term use of medications.

Calcium mefolinate, the active ingredient of Prefolic, is a salt of N5-methyltetrahydrofolate, a particularly valuable active ingredient in the treatment of folic acid deficiency conditions, often responsible for megaloblastic anemias, neurological disorders, cardiovascular diseases and cardiovascular diseases. The above-mentioned active ingredient, taken orally, enters the intestinal environment unchanged, where, thanks to the presence of specific transporters, it is absorbed in the form of mono- and diglutamates, which are immediately converted to 5-methyltetrahydrofolate, the biologically active form. Its chemical activity, important for the transfer of one-carbon units, also justifies the enormous biological significance of this molecule, participating together with vitamin B12.

Detoxification of homocysteine, a molecule with strong toxic potential and an independent risk factor for cardiovascular disease;

synthesis of methyl groups necessary for the proper functioning of numerous enzymes and biological molecules;

Synthesis of purines and, in particular, thymine, necessary for the biosynthesis of nucleic acids, therefore, for all cells in active replication, such as cells of the immune and hematopoietic system.

Indications for use

In folate deficiency anemia, as a supplier of folic acid, a catalyst for chemical processes and a stabilizer for the level of metabolic processes.

In cases of antidote therapy, as the main blocker of the side effects of methotrexate and aminopterin.

Restores after sports, being part of the Milanese cocktail, which also includes Epargresiovit, Inotin, Ezaphosphine, TAD 600 (TAD 600). The drink is aimed at the growth of active enzymes. Each drug is given in one ampoule. Start with Ezaphosphine and gradually add other drugs. The course lasts 7-10 days with a break of up to 10 days.

As part of combination therapy for the following diseases: anemia and leukopenia caused by drugs and ionizing radiation; sprue; chronic gastroenteritis; intestinal tuberculosis.

Mode of application

When using Prefolic, slow administration is recommended. Subsequently, a hematic peak occurs (after 2-3 hours), which passes over time.

The dosage for any type of administration is 15 mg per day, every two days. Application is carried out until the stage of complete remission and absolute avoidance of folic deficiency.

An exception to the dosage may be the use of Prefolic as an antidote drug. When using an increased dosage of metrotrexate or aminopterin, an increase in Prefolic dosage may be prescribed - 15 mg orally for several days, at intervals of 6-8 hours, or 50-100 mg intravenously, at intervals of 3-8 hours.

Tablets in a gastroresistant shell, i.e. active components are released in the intestines; The tablets are not chewed, but swallowed whole, optimally taken in the morning.

The possibility of use, the regimen and duration of taking Prefolic are determined by the doctor.

Side effects

Possible manifestation of allergic symptoms, fever, tachycardia, decreased blood pressure, anaphylactic shock.

Interaction with other drugs

When diagnosing pernicious anemia, Prefolic is used only together with cyanocobalamin, since it stimulates hematopoiesis - the process of formation, maturation