GUTRON ampoules 5 mg 2 ml №6

Description GUTRON ampoules 5 mg 2 ml:

Pharmacological Effects:
Alpha 1-agonists of the peripheral action. Has a vasoconstrictor effect, increases the PR and BP. Has no direct effect on adrenergic receptors of heart, heart rate, myocardial contractility, in contrast, under the action of midodrine may cause a reflex bradycardia, no effect on the tone of smooth muscles of the bronchi. Stimulating alpha-adrenergic receptors located in the sphincter of the bladder, urethra, midodrine increases their tone and has a therapeutic effect in incontinent. If you use a dose of 10 mg in patients with orthostatic hypotension increases the blood pressure of 15-30 mmHg 1 h after injection, the effect may persist for 2-3 hours


Indications:
Orthostatic hypotension (with the reactions of the type of sympathic and asimpatikotonii), idiopathic orthostatic hypotension, secondary orthostatic hypotension, hypotension (on the background of psychoactive drugs, during convalescence after surgery and childbirth), the secondary hypotension in infectious diseases, arterial hypotension with weather changes, incontinence incontinence (involuntary urination with bladder sphincter dysfunction).


Contraindications:
Hypersensitivity, hypertension, pheochromocytoma, obliterating artery diseases, peripheral artery spasm, angle-closure glaucoma, prostatic hyperplasia (with urinary retention), mechanical obstruction of the urinary tract, tireotoksikoz.C caution. CHF, arrhythmias, renal and / or liver failure, pregnancy, lactation (appointment only on strict indications).


Side effects:
From the CAS: increased blood pressure, including in the position of "lying", facial flushing, bradycardia. With the urinary system: urination disorders (more frequent or delayed). The nervous system: headache, dizziness, insomnia, somnolence, asthenia, paresthesia. From the digestive system: heartburn, dry mouth, nausea, dyspeptic disorders, flatulence. For the skin: excessive sweating, pilomotornaya reaction ("goose" the skin), pruritus, oznob.Peredozirovka. Symptoms: bradycardia, increased blood pressure, chills, "goose" the skin, urinary retention. Treatment: vomiting, gastric lavage, atropine in therapeutic doses, phentolamine.


Dosage and administration:
Doses depend on the severity of clinical symptoms and selected individually. Inside, is usually prescribed to 2.5 mg 2 times a day (1 tablet or 7 cap of 1% solution, 2 times a day), if necessary, the dose can be gradually increased at intervals of 1 week to 5 mg 2 times a day. Upon reaching the desired clinical outcome and the need for long-term treatment dose can be reduced to 1.25 mg 1-2 times per day (3 kap 1% solution of 1 times a day). B / B - 5 mg 2 times a day. The use of daily doses exceeding 30 mg is not recommended. In pediatric practice appointed on the basis of body weight.


Special instructions:
With prolonged use is necessary to monitor renal function. Banned for use in athletes (refers to doping).


Interaction:
Effect is enhanced by adrenergic and sympathomimetic ethanol; weakened - sympatholytic. Cardiac glycosides enhance bradycardia, increase the risk of AV block and arrhythmias.