Detralex 500 mg №30

Description DETRALEX ® tablets


Pharmacological properties:

venotonicheskoe and angioprotective tool. Reduces the distensibility of veins and venostaz increases their tone, improves lymphatic drainage, decreases the permeability of capillaries and increases their resistance, and improves microcirculation.
Detralex reduces the interaction of leukocytes to endothelium, adhesion of neutrophils in postkapillyarnyh venules. This reduces the damaging effects of inflammatory mediators on the walls of veins and leaf venous valves.
Detralex - the only flebotropny preparation containing purified flavonoid fraction (including diosmin and hesperidin) in micronized form. Micronization (reducing the size of the particles of active substance) for fast absorption of the active component after oral administration and a more rapid onset of action compared with nemikronizirovannoy form of diosmin.
In double placebo-controlled studies using objective and quantitative assessment of the active substance on the venous hemodynamics found that the optimal therapeutic effect in patients is achieved using the drug at a dose of 2 tablets per day, the drug is effective in the treatment of functional and organic disease of lower limb veins and proctology in the treatment of hemorrhoids.
Experimentally established that after ingestion the drug is actively metabolized in the body with the formation of phenolic acids, which are excreted in the urine. The half-life - 11 hours, Excretion of the active substance preparation is mainly through the intestine (80%). With urine output, on average 14% of the dose.

INDICATIONS:

chronic venous insufficiency of the organic and functional origin (edema, pain, feeling of heaviness in the legs). Acute and chronic hemorrhoids.

APPLICATION:

for oral administration. Assign an adult.
Treatment of symptoms of chronic venous insufficiency (edema, pain, heaviness in the legs, night cramps, trophic ulcers, lymphedema, etc.): 2 tablets per day in 2 divided doses with meals. After 1 week of application can be assigned to 2 pills a day, once during the meal.
Chronic hemorrhoids: 2 tablets per day in 2 divided doses with meals. After 1 week of application can be assigned to 2 pills a day, once during the meal.
Acute hemorrhoids: 6 tablets per day during the first 4 days and 4 pills a day for the next 3 days. Take with meals. The daily dose is divided into 2-3 doses.
Treatment. Duration of therapy depends on indication for use and the disease course. The average duration of treatment is 2-3 months.

CONTRAINDICATIONS:

Hypersensitivity to any component of the drug in history.

SIDE EFFECTS:

usual treatment may carry well. Rarely possible mild disorders of the gastrointestinal tract (diarrhea, dyspepsia, nausea, vomiting) or the autonomic nervous system (headache, dizziness) did not require discontinuation of therapy.

SPECIAL INSTRUCTIONS:

in pilot studies revealed no teratogenic effects of the drug. In clinical studies, no evidence, certificate of adverse drug effects on the fetus. Possible use of the drug in the III trimester of pregnancy. Due to the lack of data on excretion of the drug with milk, breastfeeding during its use is not recommended.
When aggravation of hemorrhoids Detralex application does not replace the specific treatment of other diseases anorectal region.
In acute hemorrhoid treatment is carried out short-course under the supervision of a physician.

INTERACTION:

not marked.

OVERDOSE:

not marked.

STORAGE:

at a temperature of 30 ° C.