• Kenalog tablets 4mg №50

Kenalog tablets 4mg №50

Trade name
KENALOG (KENALOG)

Latin name
KENALOG

General Characteristics
Triamcinolone 4 mg Other ingredients: lactose, povidone, talc, magnesium stearate, corn starch.

Form release
Table. 4 mg, № 50

Farmgruppa
Hormone medications cortex and adrenal medulla

Pharmacological properties
triamcinolone - a synthetic corticosteroids with a pronounced anti-inflammatory, antiallergic, antipruritic and immunosuppressive effects. Does not cause retention of sodium and water in the body, its diabetogenic effect is 2-3 times less pronounced than that of dexamethasone. The inhibitory effect of triamcinolone on the pituitary function is somewhat less than other corticosteroids.

Pharmacokinetics
If ingestion is rapidly absorbed in the digestive tract. The maximum concentration of triamcinolone in plasma determined cherez8-12 h after administration. The half-life of about 3.3 hours, is metabolized primarily in the liver, less - in the kidneys, about 15% preparatavyvoditsya with urine in unchanged form.

Indications for Use
All indications for the use of systemic corticosteroids therapy, including allergic diseases (allergic rhinitis and conjunctivitis, urticaria) and skin diseases (bullous dermatosis, atopic dermatitis, psoriasis, especially - in psoriatic arthritis

Dosing and Administration
dose and duration of treatment is determined individually. A drug is prescribed once daily (preferably morning) or in divided doses, especially if the total dose exceeds 16 mg. Typically, the daily dose for adults is 4-32 mg. With the development of adverse effects dosage gradually reduced (by 4 mg every 2-3 days) to achieve an adequate dose (usually 4 mg / day). Children, body mass which prevyshaet25 kg prescribed in a dose recommended for adults. Children weighing 25 kg is prescribed in an initial dose of 12 mg / day, in what dose is selected taking into account the nature of the disease, and tolerability.

Side Effects
side effects of triamcinolone are similar to those of other corticosteroids. Skin: striae, acne, petechia, ecchymosis, telangiectasia, pigmentation, delayed wound healing. Musculoskeletal system: weakness and muscle atrophy, osteoporosis with increased risk of fractures, aseptic necrosis of bone, inhibition of growth in children and adolescents. The organ of vision: glaucoma, cataracts. Digestive tract and liver: dyspeptic symptoms, nausea, anorexia, steroid ulcer, pancreatitis. Endocrine system: suppression of the adrenal cortex, Cushing syndrome, steroid diabetes, impaired secretion of sex hormones (dysmenorrhea, impotence, hirsutism), increased body weight. Immune System: immunosuppression with an increased risk of infection, masking of symptoms which developed infection is rare - allergic reactions. Blood system: the increased tendency to thrombosis. Cardiovascular system: hypertension. CNS: dizziness, golovnayabol, increased intracranial pressure, psychosis, depression

Contraindications
Hypersensitivity to triamcinolone or to other components of the drug, peptic ulcer, duodenal ulcer or anastomoses, diverticulitis, glaucoma, diabetes, osteoporosis, psychosis, lymphadenitis after BCG vaccination, a period of 2 months after vaccination with live viral vaccines, myasthenia gravis, tuberculosis, viral infections , systemic mycosis, bacterial infection (without adequate antibiotic therapy), amoebiasis, Cushing's syndrome, severe injuries and surgeries, thrombosis and thromboembolism.

Interaction with other drugs
reduces the effect of anticoagulants, high concentrations of salicylate and increases plasma glucose (requires correction dose of insulin or oral hypoglycemic agents). The simultaneous use of triamcinolone and diuretics may increase the excretion of potassium (hypokalemia in patients with increased sensitivity to cardiac glycosides). Co-administration of blockers?-Adrenoceptors increases the risk of hypokalemia. Estrogens may decrease the metabolism of corticosteroids. Co-administration of barbiturates, phenytoin or rifampicin reduces the effectiveness of triamcinolone. Triamcinolone, used in conjunction with NSAIDs increases the risk of gastrointestinal bleeding. GCS reduce the effectiveness of antihypertensive drugs.

Overdose
exceeding the recommended doses for a few weeks of development may cause Cushing's syndrome, depression of the function of the adrenal cortex, muscle weakness, osteoporosis and erosive gastroduodenopatiyu. Treatment is symptomatic. Should avoid abrupt withdrawal of the drug. A single overdose does not cause clinically significant toxicity. Hemodialysis is ineffective.

Features of
prolonged use of triamcinolone inhibits the endogenous secretion of adrenal hormones, so treatment should stop gradually. Inhibition of adrenal function may take several months after stopping treatment. Patients with a history of tuberculosis should be kept under close medical supervision, since there is a risk of reactivation of the process for the treatment of GCS, it also applies to patients with peptic ulcer. In severe infections, triamcinolone can be used only in combination with antimicrobial therapy. There is also an increased risk of viral infection through contact with patients (such as chickenpox or herpes). With carefully administered to patients with severe zabolevaniyamimyshts. Triamcinolone in children is used only when absolutely necessary, because it can inhibit the growth and development. GCS should be used with caution in patients with hypertension, severe chronic heart failure, epilepsy and severe hepatic impairment. SCS may affect the results of allergy tests, and increase the risk of hypokalemia. Safety of corticosteroids during pregnancy has not been established, their use is shown only in extreme cases, when the potential benefits for the expectant mother outweighs the potential risk to the fetus. During the treatment should stop breastfeeding. Newborns whose mothers received corticosteroids during pregnancy should be kept under medical supervision to identify the possible failure of the adrenal cortex.

Conditions and terms of
in a dark place at temperatures below 25 ° C.

Manufacturer's name and address
KRKA Slovenia

Kenalog tablets 4mg №50

  • Product Code: 55
  • Availability: In Stock
  • $16.80

  • Ex Tax: $16.80

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