DIFFERIN Gel 0,1%  30 gr

Description DIFFERIN gel 0.1%:

Release form, composition and packing
Gel 0.1% 1 g
adapalene 1 mg

Other ingredients: carbomer 980, propylene glycol, poloxamer 182, sodium edetate, metilparagidroksibenzoat, phenoxyethanol, sodium hydrochloride, distilled water.
30 g - Plastic Tubes (1) - packs cardboard.
Cream 0.1% 1 g
adapalene 1 mg

Other ingredients: carbomer 934R, PEG-20, glycerin, natural perhydrosqualene, metilparagidroksibenzoat, propilparagidroksibenzoat, sodium edetate, methylglucose seskistearat, Phenoxyethanol, Cyclomethicone, Sodium hydroxide, pp 10% distilled water.
30 g - tuba (1) - packs cardboard.

Registration № №:
# Gel 0.1%: 30 g of a tuba - P № 012654/01-2001 06.02.01
# 0.1% cream: 30 g of a tuba - P № 012654/02-2001 06.02.01

Pharmacological action

Adapalene represents a new generation of synthetic retinoids and is a derivative of naphthoic acid. Adapalene has sebostaticheskim, komedonoliticheskim / antikomedogennym and anti-inflammatory action.
The drug acts on the follicular hyperkeratosis, regulating the process of keratinization and desquamation - has expressed komedonoliticheskoy activity (effect on open and closed comedones) and antikomedogennym effect (prevents mikrokomedonov).
The main mechanism of action - selective binding to the nuclear RAg-receptor cells in the epidermis in contrast to the indiscriminate binding of synthetic retinoids previous generations. This mechanism regulates the final differentiation of keratinocytes, which provides the normalization process of keratinization and a decrease in the prerequisites for the formation of mikrokomedonov.
Proved a pronounced anti-inflammatory effect of adapalene: inhibition of lipoxygenase, arihidonovoy acids, cytokines. In vitro and in vivo shows a high anti-inflammatory activity, comparable in potency with betamethasone and indomethacin, by influencing factors of inflammation.
Adapalene has no photosensitizing effect.

Pharmacokinetics

Due to low systemic absorption data on the pharmacokinetics of the drug Differin no.

Statement

   - Eels.

Dosing regimen

Cream or gel uniformly, without rubbing, applied to affected skin 1 time / day before bedtime. The drug should be applied on clean, dry skin.
The therapeutic effect develops after 4-8 weeks of therapy, sustained improvement - in 3 months from start of therapy.
Possible to conduct repeated courses of drug therapy on the advice of a doctor.
Differin Cream is recommended for dry and sensitive skin.

Side effect

Local reaction: when applying cream or gel in excessive amounts may redness and peeling.

Contraindications

   - Hypersensitivity to the drug.

Pregnancy and lactation

Differin does not recommend use during pregnancy and lactation (breastfeeding).

Cautions

Using the drug should avoid falling into the eyes and lips.
In some cases, the application of the drug possible short-term irritation of the skin, in such cases, therapy can be interrupted before the disappearance of signs of irritation.
During the period of the drug should be avoided active in the sun and UV exposure due to possible mild skin irritation.
During the period of the drug does not recommend the use of cosmetic products with Dries up oily or irritating effect (including perfume, etanolsoderzhaschie means).
Possible to use other means for the treatment of acne during treatment Differina, with Differin used 1 time per day at bedtime and morning use other means (eg, 4% lotion, erythromycin, clindamycin 1% lotion, benzoyl peroxide, water-based in a concentration not exceeding 10%). The simultaneous use of makeup and moisturizers are not conducive to the formation of comedones.

Overdose

Due to low systemic absorption of an overdose is unlikely.

Drug Interactions

Not established clinically significant drug interactions Differin, while the application of clindamycin phosphate and benzoyl peroxide.

Conditions and terms of

Adapalene - the active ingredient in Differin, is resistant to oxygen and light, chemically inactive.
The gel should be stored at temperatures not above 25 ° C, the reach of children. Shelf life - 3 years.
The cream should be stored at temperatures not above 25 ° C, the reach of small children, do not freeze. Shelf life - 2 years.
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The drug is approved for use as a means OTC.